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A Speedy One Pot Synthesis of Second Gen

Giancarlo Cravotto, Luisa Boffa

2026enionic liquidsone-pot synthesismicrowave irradiationultrasoundgreen chemistryMenshutkin reaction

Abstract

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The present work describes an efficient one-pot synthesis of second-generation ionic liquids (ILs), combining in one step the Menshutkin reaction and anion metathesis. Working in a closed vessel under microwaves, or better still under simultaneous ultrasound and/or microwave irradiation, in a few minutes a series of ILs with 1-methylimidazole or pyridine cores were obtained in high yields (80–97% isolated). Under conventional heating, ILs could not be prepared in one pot in acceptable times and yields, whereas our protocol, carried out with commercially available equipment, was highly effective and reproducible. Moreover, 1H NMR analysis and ion-exchange chromatography showed that the present solventless procedure afforded satisfyingly pure ILs.

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Cite This Work

@article{02547d60-3e6f-4f21-a01c-eeaa11a2f834,
  title={A Speedy One Pot Synthesis of Second Gen},
  author={Giancarlo Cravotto and Luisa Boffa},
  year={2026},
  language={en}
}
TY  - JOUR
TI  - A Speedy One Pot Synthesis of Second Gen
AU  - Giancarlo Cravotto
AU  - Luisa Boffa
PY  - 2026
LA  - en
ER  -

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