John R Roche, Dawn E Dalley
This study investigates the impact of a metabolically induced systemic acidosis on calcium (Ca) homeostasis and the diurnal variation of urine pH in non-lactating pregnant dairy cows. The objective was to examine the effects of varying dietary cation-anion difference (DCAD) levels on urine pH and Ca absorption. Eight non-lactating, pregnant Holstein-Friesian cows were subjected to two DCAD levels (–20 and +18 meq/100 g DM) over 24 days, followed by a metabolism study analyzing urine and faeces for Ca content. Findings indicated that a lower DCAD decreased urine pH (P<0·001) and enhanced Ca absorption (P<0·05), without significantly affecting plasma Ca concentrations or urinary hydroxyproline output, a bone resorption marker. Crucially, the study found no diurnal variation in urine pH, suggesting that urine sampling could be flexible without affecting the outcome of efficacy assessment for DCAD. The results imply that anionic salt supplementation can successfully reduce systemic pH, thus increasing gastrointestinal Ca absorption without necessitating strict timing of urine sampling.
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title={Effect of a metabolically created system},
author={John R Roche and Dawn E Dalley},
year={2026},
language={en}
}TY - JOUR TI - Effect of a metabolically created system AU - John R Roche AU - Dawn E Dalley PY - 2026 LA - en ER -
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