Li-na Niu, Jia-qi Sun
The aim of this study was to investigate the effect of intrafibrillar-silicified collagen scaffolds on the osteogenic potential of human dental pulp stem cells (hDPSCs). Utilizing a comparative approach, hDPSCs were cultured on intrafibrillar-silicified collagen scaffolds under osteogenic differentiation medium (ODM) for two weeks, followed by subcutaneous implantation in immunocompromised mice. The assessment of osteogenic potential involved evaluating gene expression levels and newly formed capillaries within the scaffolds. Results demonstrated that hDPSCs cultured on silicified scaffolds exhibited significantly enhanced osteogenic markers compared to control groups, indicating the scaffolds' efficacy in promoting osteogenic differentiation. Additionally, vascularization was observed within the scaffolds, suggesting that the microenvironment created by silicified collagen supports both osteogenesis and angiogenesis. This study provides evidence that intrafibrillar-silicified collagen scaffolds can effectively enhance the osteogenic capacity of hDPSCs, offering promising implications for regenerative dentistry and tissue engineering applications.
@article{0be059fd-40ac-4889-9c15-238d261a66b1,
title={Intrafibrillar-silicified collagen scaffolds enhance the osteogenic capacity of human dental pulp stem cells},
author={Li-na Niu and Jia-qi Sun},
year={2014},
language={en}
}TY - JOUR TI - Intrafibrillar-silicified collagen scaffolds enhance the osteogenic capacity of human dental pulp stem cells AU - Li-na Niu AU - Jia-qi Sun PY - 2014 LA - en ER -
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