Erdinc Kamer, Haluk Recai Unalp
Abdominal wall repair after celiotomy is important because insufficient incisional wound strength results in wound failures such as fascial dehiscence and herniation. Ascorbic acid has been shown to play an important role in wound healing. The purpose of this study was to investigate whether ascorbic acid improves incisional wound healing in a diabetic rat. Male Wistar-Albino streptozosin-induced diabetic rats (n = 20) were divided into two groups: control group (CG; n = 10) and daily 200 mg/kg ascorbic acid (study group, SG, n = 10) given orally. Ten animals from each group were euthanized on postoperative day (POD) 14 after wounding; breaking strength, histologic examination, and tissue hydroxyproline levels were analyzed. The hydroxyproline tissue content of the abdominal fascia in the ascorbic acid treatment group was superior to the control group, and the difference was statistically significant (P < 0.05). The tensiometric analyses revealed that tensile strength for the midline incision was significantly higher in the study group compared to the control group (P < 0.05). Significant differences were found in the results of histologic examination of tissue specimens between the two groups regarding acute inflammation, chronic inflammation, granulati on tissue fibroblast maturation, collagen deposition, and neovascularization on POD 14 (P < 0.05). The present study demonstrates that administration of ascorbic acid prior to laparotomy improves incisional wound healing.
@article{0da3b9a1-6f87-402b-a198-9f90cc86772e,
title={Effect of Ascorbic Acid on Incisional Wound Healing in Streptozotocin-Induced Diabetic Rats},
author={Erdinc Kamer and Haluk Recai Unalp},
year={2010},
language={en}
}TY - JOUR TI - Effect of Ascorbic Acid on Incisional Wound Healing in Streptozotocin-Induced Diabetic Rats AU - Erdinc Kamer AU - Haluk Recai Unalp PY - 2010 LA - en ER -
Jennifer Namias, Dr. Nickolas J. Themelis
This study explores the future of electronic waste recycling in the United States, addressing the challenges and proposing domestic solutions. The rap
Alain Vignes
This book provides a comprehensive overview of the fundamental principles of extractive metallurgy, with a specific focus on basic thermodynamics and
Alain Vignes
Extractive metallurgy is a critical field that encompasses the processes involved in the extraction of valuable metals from their ores. This work serv
Arthur C. Reardon
This publication, edited by Arthur C. Reardon and published by ASM International®, serves as a comprehensive guide in the field of materials science.
P Card, J Canterford
This document presents a collection of papers from the METPLANT 2011 conference focusing on metallurgical plant design and operating strategies. The o
David Pollard, Geoff Dunlop
The MetPlant 2008 conference focused on advancements in metallurgical processing of ores, emphasizing plant design, operation strategies, and innovati