J S Ross, K Wang
Adrenocortical carcinoma (ACC) carries a poor prognosis and current systemic cytotoxic therapies result in only modest improvement in overall survival. In this retrospective study, we performed a comprehensive genomic profiling of 29 consecutive ACC samples to identify potential targets of therapy not currently searched for in routine clinical practice. DNA from 29 ACC was sequenced to high, uniform coverage (Illumina HiSeq) and analysed for genomic alterations (GAs). At least one GA was found in 22 (76%) ACC (mean 2.6 alterations per ACC). The most frequent GAs were in TP53 (34%), NF1 (14%), CDKN2A (14%), MEN1 (14%), CTNNB1 (10%) and ATM (10%). APC, CCND2, CDK4, DAXX, DNMT3A, KDM5C, LRP1B, MSH2 and RB1 were each altered in two cases (7%) and EGFR, ERBB4, KRAS, MDM2, NRAS, PDGFRB, PIK3CA, PTEN and PTCH1 were each altered in a single case (3%). In 17 (59%) of ACC, at least one GA was associated with an available therapeutic or a mechanism-based clinical trial. Next-generation sequencing can discover targets of therapy for relapsed and metastatic ACC and shows promise to improve outcomes for this aggressive form of cancer.
@article{13369736-6ed1-4e00-94d9-0a3040523b90,
title={Magnetohydrodynamics in Materials Proces},
author={J S Ross and K Wang},
year={2026},
language={en}
}TY - JOUR TI - Magnetohydrodynamics in Materials Proces AU - J S Ross AU - K Wang PY - 2026 LA - en ER -
Unknown, Unknown
This chapter discusses metal casting processes, highlighting the diversity and common characteristics among them. The objective is to elucidate the fu
Unknown, Unknown
This study focuses on the fundamental characteristics of solid iron, which is predominantly composed of iron atoms and provides a basis for understand
Ir. Méshac KIME ILUNGA
Ce document traite des procédés métallurgiques spéciaux, en mettant particulièrement l'accent sur l'extraction liquide-liquide, un processus mis au po
Copper solvent extraction units at large hydrometallurgical plants face constraints in metal recovery, phase disengagement, and reagent consumption, d
Non spécifié
L'hydrométallurgie du cuivre, principalement axée sur les minerais oxydés facilement solubles, s'applique également aux minerais sulfurés ou mixtes ap