Pankaj Seth, Frank Diaz
Since the initial description of progressive multifocal leukoencephalopathy (PML) in 1958, clinical and basic science investigators have demonstrated a growing interest in the area of neurovirology, with a recent focus on polyomaviruses. This review presents an overview of the biological properties of the human polyomavirus, JC virus (JCV), and its association with PML as the etiologic agent. Additionally, we discuss the current understanding of JCV molecular pathogenesis and therapeutic strategies. By examining the properties of JCV and its effects leading to PML, we provide insights into the mechanisms of demyelination and potential avenues for treatment. Our findings illustrate the complexity of JC virus interactions within the host and highlight the importance of understanding its molecular biology for therapeutic development.
@article{3d163a2b-72ef-4531-b5e1-686cb011d1f3,
title={Advances in the Biology of JC Virus and},
author={Pankaj Seth and Frank Diaz},
year={2026},
language={en}
}TY - JOUR TI - Advances in the Biology of JC Virus and AU - Pankaj Seth AU - Frank Diaz PY - 2026 LA - en ER -
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