Florence Teulé, Yun-Gen Miao
The development of a spider silk-manufacturing process is of great interest due to the limitations associated with natural spider farming and existing recombinant protein production platforms. This study aimed to engineer transgenic silkworms that produce chimeric silkworm/spider silk proteins, utilizing piggyBac vectors for gene transfer. The resultant silk fibers from the transgenic silkworms exhibited composite properties, demonstrating an integration of chimeric silk proteins in a stable manner. Mechanical testing revealed that these composite fibers were tougher than traditional silkworm silk and comparable in toughness to native dragline spider silk. The findings provide evidence that silkworms can be successfully engineered to synthesize composite silk fibers with significantly enhanced mechanical properties, thereby enhancing their potential for applications in various biomaterials such as sutures and tissue scaffolds.
@article{623f0bcb-5c40-4000-a86e-9990b5d556bf,
title={Silkworms transformed with chimeric silk},
author={Florence Teulé and Yun-Gen Miao},
year={2026},
language={en}
}TY - JOUR TI - Silkworms transformed with chimeric silk AU - Florence Teulé AU - Yun-Gen Miao PY - 2026 LA - en ER -
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