Electrospinning Production of PLLA Fibro

Nonwoven fibrous mats were produced through the process of solution electrospinning, using poly(L-lactic) acid (PLLA), a biodegradable and biocompatible polymer. This study aimed to investigate the morphology and degradation rate of the produced fibrous mats. Scanning electron microscopy was employed to examine the obtained fibres, which displayed a porous surface with diameters ranging from 200 nm to 1.2 µm, influenced by various process parameters such as solvent type, solution concentration, flow rate, applied voltage, and setup geometry. Additionally, the effect of polymer concentration on solution viscosity was assessed. The degradation rate of the fibres was measured to evaluate their suitability as long-term biodegradable scaffolds in tissue engineering applications, particularly for bone, vascular, and cartilage tissues. The findings indicate that materials synthesized via the electrospinning process possess a promising potential for use in scaffolding, addressing critical aspects such as cell migration, adhesion, growth, and regeneration matching the natural tissues. Thus, PLLA fibrous scaffolds demonstrate significant applicability in the advancement of tissue engineering.