Electrospun nanostructured scaffolds for

Despite being known for decades, electrospinning has emerged recently as a widespread technology for producing synthetic nanofibrous structures. These structures have morphologies and fiber diameters comparable to those found in the extracellular matrix of human tissues, thereby providing improved environments for cell attachment, migration, proliferation, and differentiation compared to traditional scaffolds. This report aims to explore the versatility of electrospun nanofibers, including the potential for local drug-release systems due to their highly specific surface area. While common electrospun nanofiber meshes exhibit random fiber orientation, aligned distributions and interconnected microporous structures can also be achieved. However, the pore sizes and planar structures of these meshes can hinder cell infiltration into inner regions, potentially compromising tissue regeneration. Various strategies to overcome these limitations are discussed, emphasizing the creation of biocompatible scaffolds that physically support cells and mimic native tissue characteristics. This interdisciplinary field aims to develop biological substitutes that restore, maintain, or improve tissue function or whole organs, highlighting the critical need for innovative scaffolding solutions in regenerative medicine.