PDF

High-Throughput White Blood Cell (Leukocyte) Enrichment from Whole Blood Using Hydrodynamic and Inertial Forces

Batzorig Lombodorj, Horas Cendana Tseng

2020enblood separationmicrofluidicsleukocytes

Abstract

Language:

A microfluidic chip, which can separate and enrich leukocytes from whole blood, is proposed. The chip has 10 switchback curve channels, which are connected by straight channels. The straight channels are designed to permit the inertial migration effect and to concentrate the blood cells, while the curve channels allow the Dean flow to further classify the blood cells based on the cell sizes. Hydrodynamic suction is also utilized to remove smaller blood cells (e.g., red blood cell (RBC)) in the curve channels for higher separation purity. By employing the inertial migration, Dean flow force, and hydrodynamic suction in a continuous flow system, our chip successfully separates large white blood cells (WBCs) from the whole blood with the processing rates as high as 1 × 10^8 cells/sec at a high recovery rate at 93.2% and very few RBCs (~0.1%).

Download

Cite This Work

@article{88bae660-9aaa-4411-9c01-1697230e5b8d,
  title={High-Throughput White Blood Cell (Leukocyte) Enrichment from Whole Blood Using Hydrodynamic and Inertial Forces},
  author={Batzorig Lombodorj and Horas Cendana Tseng},
  year={2020},
  language={en}
}
TY  - JOUR
TI  - High-Throughput White Blood Cell (Leukocyte) Enrichment from Whole Blood Using Hydrodynamic and Inertial Forces
AU  - Batzorig Lombodorj
AU  - Horas Cendana Tseng
PY  - 2020
LA  - en
ER  -

Similar Items

Effect of Roasting Temperature for Copper Leaching of Sulfide Concentrate by Combined Methods

Lkhamtogmid Nyamjargal, Ganbat Batdemberel, Gunchin Burmaa, Dashdendev Burmaa

This study was undertaken to develop a cost-effective method of copper leaching in sulfide concentrate involving minerals as chalcopyrite and pyrite.

2018enPDF

Effect of Roasting Temperature for Copper Leaching of Sulfide Concentrate by Combined Methods

Introduction Concerns over air pollution and the environmental problem of acid rain have made governments all over the world tighten their regulations

2023enPDF

A Study of Ferrospheres in the Coal Fly Ash

Danzandorj Sunjidmaa, Ganbat Batdemberel

Coal fly ash is an industrial by-product produced from coal combustion in thermal power plants. It is a complex anthropogenic material consisting of v

2019enPDF

Content Analysis of Educational Psychology Journals

John Doe, Jane Smith

This study aims to analyze the content of leading educational psychology journals to identify trends and gaps in research. The objective is to assess

2023enPDF

Probes of motivation and emotion in action: A neurocognitive approach

John Doe, Jane Smith

This study explores the interrelation between motivation and emotion within the framework of neurocognitive mechanisms. The objective is to understand

2023enPDF

Glossary

This glossary serves as a comprehensive compilation of key terms and concepts related to materials science and chemistry. The objective is to provide

2023enPDF