Modeling of Elution Curves in Preparative Chromatography Using Anion-Exchange Resin for Cobalt Purification

This study investigates the modeling of elution and breakthrough curves in ion-exchange chromatography, with a particular focus on the purification of high-purity cobalt using an anion-exchange resin. The objective is to develop a precise mathematical model that accurately represents the elution curves, which is essential to enhance the yield and purity of the product. A novel model, referred to as the plate theory in multi-path mode, is proposed, which assumes three virtual paths for replication of elution curves. The methodology involves optimizing purification conditions for various metals through experimental trials and validating the model by comparing distribution coefficients derived from fitting results with those obtained from existing batch experiments. The results demonstrate that the proposed model effectively captures the characteristics of experimental elution curves, highlighting its significance for future applications in ion-exchange chromatography and the necessity for accurate modeling to minimize experimental phases in metal purification. This research contributes to the advancement of efficient purification processes needed for modern materials used in electronic devices.