Cyphenothrin disrupts the integrity of porcine trophectoderm and u 2026 Chem

Despite the widespread use of pyrethroid insecticides in domestic, agricultural, and veterinary settings, their potential health risks, particularly those affecting female reproduction, remain a concern. Cyphenothrin, a Type II pyrethroid commonly used for household pest control and veterinary purposes, has not been well characterized with respect to female reproductive toxicity. This study therefore examined the impact of cyphenothrin on porcine trophectoderm and uterine luminal epithelial cell lines, focusing on its effects on cell viability, apoptosis, mitochondrial superoxide production, and intracellular reactive oxygen species (ROS) levels. Additionally, the research investigated alterations in calcium homeostasis and mitophagy induced by cyphenothrin exposure. The results indicated that cyphenothrin significantly reduced cell viability, promoted apoptotic cell death, and disrupted mitochondrial function leading to increased ROS levels. Furthermore, it was found that cell migration was impaired, potentially contributing to negative effects on implantation. Overall, the findings highlight the reproductive toxicity of cyphenothrin, suggesting potential implications for female reproductive health and embryo implantation processes.