Dharmesh R. Tailor, Arijit Roy
Proton T1-dispersion MRI is demonstrated for indirect, in vivo detection of 17O in the brain. This technique, which may be readily implemented on any clinical MRI scanner, is applied towards high-resolution, quantitative mapping of cerebral blood flow (CBF) in the rat by monitoring the clearance of 17O-enriched water. Strategies are derived and employed for quantitation of absolute H2O tracer concentration from a ratio of high-and-low-frequency spin-locked T1 images, and mapping CBF through having to transform the T1 signal to H2O tracer concentration. Absolute regional blood flow was mapped in a single 3-mm brain slice at an in-plane resolution of 0.4 × 0.8 mm within a 5-min tracer washout time; these data are consistent with the less localized CBF measurements reported in the literature. T1-weighted imaging yields excellent signal-to-noise ratios, spatial temporal resolution, and anatomical contrast for mapping CBF.
@article{b39606b9-37e5-4ccd-8933-22bfc607b5d0,
title={Indirect17O magnetic resonance imaging o},
author={Dharmesh R. Tailor and Arijit Roy},
year={2026},
language={en}
}TY - JOUR TI - Indirect17O magnetic resonance imaging o AU - Dharmesh R. Tailor AU - Arijit Roy PY - 2026 LA - en ER -
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