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Optimization of the reaction conditions

Jiangning Wu, K. E. Taylor

2026enwastewaterphenol removalenzymeshorseradish peroxidasepolyethylene glycolreaction optimization

Abstract

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The study investigates the effect of polyethylene glycol (PEG) as an additive on the horseradish peroxidase (HRP) catalyzed removal of phenol from wastewater across a concentration range of 1-10 mM. The primary objective is to optimize various reaction conditions including pH, HRP concentration, PEG concentration, and the molar ratio of hydrogen peroxide to phenol, aiming to maximize phenol removal efficiency while minimizing costs. The methodology includes experimental trials conducted at room temperature to assess the protective effect of PEG on HRP activity and its impact on reaction time. Findings reveal that the addition of PEG significantly enhances HRP effectiveness, reducing the amount needed for phenol solutions by 40-75 times compared to reactions without PEG. The optimum conditions determined are a pH of 8.0 and a hydrogen peroxide to phenol molar ratio of approximately 1.0. Reaction times for achieving at least 95% removal of phenol are recorded as 5 hours for 1 mM and 3 hours for 10 mM solutions. Additionally, while increasing HRP concentration notably decreases reaction time, changes in PEG concentration have little effect on this metric.

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Cite This Work

@article{f3b66e99-42a1-4c64-91f6-910659fe0e2d,
  title={Optimization of the reaction conditions},
  author={Jiangning Wu and K. E. Taylor},
  year={2026},
  language={en}
}
TY  - JOUR
TI  - Optimization of the reaction conditions
AU  - Jiangning Wu
AU  - K. E. Taylor
PY  - 2026
LA  - en
ER  -

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